Lead: Dr Markus Antwerpen

The Microbial Genomics and Bioinformatics division works in the field of microbial forensics and ensures the (whole genome) sequencing capacity of the institute.

The focus is on next-generation sequencing, which allows not only the examination of individual genomes, but also the comparison of the genetic sequences of several different genomes in a short period of time. These approaches can be used to identify acquired resistance and virulence genes or to support traceability analyses in a bioforensic investigation among others. It is therefore a key technology for the development of molecular diagnostics, but also for outbreak investigations. 

The division collaborates closely with the Central Diagnostics Unit, Department for Bacteriology and Department for Virology as well as the reference laboratories. Its bioinformaticians generate, analyse, and evaluate genomic and metagenomic information from relevant test materials and make it available to their colleagues. Additionally, the division develops and establishes appropriate methods or processes for sample processing and data evaluation. The knowledge gained from the results is incorporated into the diagnostic algorithms used and enables rapid adaptation to current events.
Where technically and scientifically appropriate, it also collaborates with national and international partners from the military and civilian scientific communities.

Projects

• Comparative genomic analyses in the context of outbreak investigations
• Evaluation of site-independent sequencing using novel instrument platforms
• Use of metagenomic analysis to support pathogen identification in clinical samples